| Thursday, October 5th | ||
| Western Kentucky at Louisiana Tech | 7:00 PM | ESPN |
| Friday, October 6th | | |
| Kansas State at Oklahoma State | 6:30 PM | ESPN |
| Nebraska at Illinois | 7:00 PM | FS1 |
| Saturday, October 7th | ||
| Boston College at Army | 11:00 AM | CBSSN |
| LSU at Missouri | 11:00 AM | ESPN |
| Maryland at Ohio State | 11:00 AM | FOX |
| Oklahoma vs. Texas (Dallas) | 11:00 AM | ABC |
| Toledo at UMass | 11:00 AM | ESPNU |
| Western Michigan at Mississippi State | 11:00 AM | SECN |
| William & Mary at Virginia | 11:00 AM | ACCN |
| Marshall at NC State | 1:00 PM | CWTV |
| Howard at Northwestern | 2:00 PM | BTN |
| Washington State at UCLA | 2:00 PM | Pac-12 |
| Alabama at Texas A&M | 2:30 PM | CBS |
| North Texas at Navy | 2:30 PM | CBSSN |
| Syracuse at North Carolina | 2:30 PM | ESPN |
| Texas State at Louisiana Lafayette | 2:30 PM | ESPNU |
| Virginia Tech at Florida State | 2:30 PM | ABC |
| Wake Forest at Clemson | 2:30 PM | ACCN |
| South Florida at UAB | 3:00 PM | ESPN2 |
| UCF at Kansas | 3:00 PM | FOX |
| Vanderbilt at Florida | 3:00 PM | SECN |
| Colorado at Arizona State | 5:30 PM | Pac-12 |
| Florida A&M at Southern | 6:00 PM | ESPNU |
| Kentucky at Georgia | 6:00 PM | ESPN |
| Arkansas at Ole Miss | 6:30 PM | SECN |
| Michigan at Minnesota | 6:30 PM | NBC |
| Notre Dame at Louisville | 6:30 PM | ABC |
| Fresno State at Wyoming | 7:00 PM | FOX |
| Georgia Tech at Miami | 7:00 PM | ACCN |
| San Jose State at Boise State | 7:00 PM | CBSSN |
| TCU at Iowa State | 7:00 PM | FS2 |
| Texas Tech at Baylor | 7:00 PM | ESPN2 |
| Oregon State at Cal | 9:00 PM | Pac-12 |
| Arizona at USC | 9:30 PM | ESPN |