| Wednesday, October 5th | ||
| SMU at UCF | 6:00 PM | ESPN2 |
| Friday, October 7th | ||
| Nebraska at Rutgers | 6:00 PM | FS1 |
| Houston at Memphis | 6:30 PM | ESPN2 |
| Colorado State at Nevada | 9:30 PM | FS1 |
| UNLV at San Jose State | 9:30 PM | CBSSN |
| Saturday, October 8th | ||
| Arkansas at Mississippi State | 11:00 AM | SECN |
| Buffalo at Bowling Green | 11:00 AM | espn+ |
| Eastern Michigan at Western Michigan | 11:00 AM | CBSSN |
| Louisville at Virginia | 11:00 AM | ACCN |
| Michigan at Indiana | 11:00 AM | FOX |
| Missouri at Florida | 11:00 AM | ESPNU |
| Oklahoma vs. Texas (Dallas, TX) | 11:00 AM | ABC |
| Purdue at Maryland | 11:00 AM | BTN |
| TCU at Kansas | 11:00 AM | FS1 |
| Tennessee at LSU | 11:00 AM | ESPN |
| Akron at Ohio | 1:00 PM | espn3 |
| Georgia Southern at Georgia State | 1:00 PM | espn3 |
| South Florida at Cincinnati | 1:30 PM | espn+ |
| Kentucky State at Lane | 2:00 PM | espn+ |
| Auburn at Georgia | 2:30 PM | CBS |
| Ball State at Central Michigan | 2:30 PM | espn+ |
| East Carolina at Tulane | 2:30 PM | ESPNU |
| Kent State at Miami Ohio | 2:30 PM | espn+ |
| Liberty at UMass | 2:30 PM | espn+ |
| MTSU at UAB | 2:30 PM | Stadium |
| Texas Tech at Oklahoma State | 2:30 PM | FS1 |
| Toledo at Northern Illinois | 2:30 PM | espn+ |
| Tulsa at Navy | 2:30 PM | CBSSN |
| Utah at UCLA | 2:30 PM | FOX |
| Virginia Tech at Pittsburgh | 2:30 PM | ACCN |
| Wisconsin at Northwestern | 2:30 PM | BTN |
| Duke at Georgia Tech | 3:00 PM | espn3 |
| North Carolina at Miami | 3:00 PM | ESPN2 |
| Ohio State at Michigan State | 3:00 PM | ABC |
| Ole Miss at Vanderbilt | 3:00 PM | SECN |
| Washington at Arizona State | 3:00 PM | Pac-12 |
| Illinois State at Northern Iowa | 4:00 PM | espn+ |
| Western Kentucky at UTSA | 5:00 PM | espn+ |
| Air Force at Utah State | 6:00 PM | FS1 |
| Appalachian State at Texas State | 6:00 PM | espn+ |
| James Madison at Arkansas State | 6:00 PM | NFLN |
| Southern Miss at Troy | 6:00 PM | espn+ |
| UTEP at Louisiana Tech | 6:00 PM | espn+ |
| Wyoming at New Mexico | 6:00 PM | CBSSN |
| Army at Wake Forest | 6:30 PM | espn3 |
| BYU vs. Notre Dame (Las Vegas) | 6:30 PM | NBC |
| Clemson at Boston College | 6:30 PM | ABC |
| Iowa at Illinois | 6:30 PM | BTN |
| Kansas State at Iowa State | 6:30 PM | ESPNU |
| South Carolina at Kentucky | 6:30 PM | SECN |
| Washington State at USC | 6:30 PM | FOX |
| Coastal Carolina at Louisiana Monroe | 7:00 PM | espn+ |
| Florida State at NC State | 7:00 PM | ACCN |
| Texas A&M at Alabama | 7:00 PM | CBS |
| Oregon at Arizona | 8:00 PM | Pac-12 |
| Fresno State at Boise State | 8:45 PM | FS1 |
| Hawaii at San Diego State | 9:30 PM | CBSSN |
| Oregon State at Stanford | 10:00 PM | ESPN |
