| Friday, September 27th | | |
| Virginia Tech at Miami | 6:30 PM | ESPN |
| Washington at Rutgers | 7:00 PM | FOX |
| | | |
| Saturday, September 28th | | |
| Kentucky at Ole Miss | 11:00 AM | ABC |
| Minnesota at Michigan | 11:00 AM | FOX |
| BYU at Baylor | 11:00 AM | FS1 |
| Oklahoma State at Kansas State | 11:00 AM | ESPN |
| Maryland at Indiana | 11:00 AM | BTN |
| Nebraska at Purdue | 11:00 AM | Peacock |
| Western Kentucky at Boston College | 11:00 AM | ACCN |
| Holy Cross at Syracuse | 11:00 AM | ACCNX |
| Northern Illinois at North Carolina State | 11:00 AM | The CW |
| Arkansas at Texas A&M | 2:30 PM | ESPN |
| Wisconsin at USC | 2:30 PM | CBS |
| Colorado at UCF | 2:30 PM | FOX |
| Oklahoma at Auburn | 2:30 PM | ABC |
| TCU at Kansas | 2:30 PM | ESPN+ |
| Louisville at Notre Dame | 2:30 PM | Peacock |
| Louisiana at Wake Forest | 2:30 PM | ACCN |
| North Carolina at Duke | 3:00 PM | ESPN2 |
| Mississippi State at Texas | 3:15 PM | SECN |
| Stanford at Clemson | 6:00 PM | ESPN |
| Iowa State at Houston | 6:00 PM | FS1 |
| Georgia at Alabama | 6:30 PM | ABC |
| Illinois at Penn State | 6:30 PM | NBC |
| Ohio State at Michigan State | 6:30 PM | Peacock |
| South Alabama at LSU | 6:45 PM | SECN |
| Cincinnati at Texas Tech | 7:00 PM | ESPN2 |
| Florida State at SMU | 7:00 PM | ACCN |
| Arizona at Utah | 9:15 PM | ESPN |
| Oregon at UCLA | 10:00 PM | FOX |