| Thursday, October 25th | ||
| Syracuse at Pittsburgh | 6:30 PM | ESPN |
| Friday, October 25th | | |
| Louisville at Boston College | 6:30 PM | ESPN |
| Rutgers at USC | 10:00 PM | FOX |
| | | |
| Saturday, October 26th | | |
| Nebraska at Ohio State | 11:00 AM | FOX |
| Oklahoma at Ole Miss | 11:00 AM | ESPN |
| Washington at Indiana | 11:00 AM | BTN |
| Georgia Tech at Virginia Tech | 11:00 AM | ACCN |
| North Carolina at Virginia | 11:00 AM | The CW |
| Arkansas at Mississippi State | 11:45 AM | SECN |
| Missouri at Alabama | 2:30 PM | ABC |
| Illinois at Oregon | 2:30 PM | CBS |
| Texas Tech at TCU | 2:30 PM | FOX |
| BYU at UCF | 2:30 PM | ESPN |
| Maryland at Minnesota | 2:30 PM | FS1 |
| Wake Forest at Stanford | 2:30 PM | ACCN |
| Oklahoma State at Baylor | 2:30 PM | ESPN+ |
| Northwestern at Iowa | 2:40 PM | BTN |
| Oregon State at California | 3:00 PM | ESPN2 |
| Texas at Vanderbilt | 3:15 PM | SECN |
| Florida State at Miami | 6:00 PM | ESPN |
| West Virginia at Arizona | 6:00 PM | FS1 |
| Utah at Houston | 6:00 PM | ESPN+ |
| LSU at Texas A&M | 6:30 PM | ABC |
| Auburn at Kentucky | 6:45 PM | SECN |
| Kansas at Kansas State | 7:00 PM | ESPN2 |
| SMU at Duke | 7:00 PM | ACCN |
| Cincinnati at Colorado | 9:15 PM | ESPN |